Label: VIAGRA- sildenafil citrate tablet, film coated

Sildenafil tablets (20 mg; Revatio, generic), sildenafil oral suspension (Revatio, generic), and sildenafil injection (Revatio, generic) are used for PAH. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation. In erectile dysfunction (ED), this increases blood flow to penile tissue, facilitating an erection. In pulmonary arterial hypertension (PAH), it dilates pulmonary vessels by the same mechanism, reducing pulmonary blood pressure and improving exercise capacity. Sildenafil first gained FDA approval on March 27, 1998. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers".

• Pfizer Sildenafil 100mg can cause priapism; seek medical help if it lasts over 4 hours.
• Check with your doctor about possible drug interactions before starting.
• Avoid grapefruit juice when taking sildenafil, as it can affect absorption.
• If you experience chest pain, seek emergency medical attention.
• Use only the prescribed dosage; overdose can be dangerous.

Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

• Sildenafil 100mg may interact with other medications, like antidepressants.
• Do not use if you have a history of allergic reactions to sildenafil.
• The medication can cause vision changes, such as blurred vision.
• Use caution if you have kidney or liver problems.
• Regular exercise and a healthy diet support erectile health.

Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). The most common side effects of sildenafil tablets for ED are: Abnormal vision, such as changes in color vision (such as having a blue color tinge) andblurred vision The most common side effects of sildenafil oral film for ED are: Abnormal vision, such as changes in color and blurred vision The most common side effects of sildenafil tablets/ oral suspension, and injection for PAH are: Sildenafil can cause the following serious side effects. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. Stop taking sildenafil and call your healthcare provider right away if you havesudden vision loss in one or both eyes.

If you have these symptoms, stop taking sildenafil and contact a doctor right away. In addition, heart attack, stroke, irregular heartbeats, and death have happened rarely in people taking sildenafil.

12.1 Mechanism of Action

doi:10.1331/1544345052843165. «Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time». International Journal of Impotence Research 15 (3): 225-228. «The rise of Viagra among British illicit drug users: 5-year survey data». Drug and Alcohol Review 25 (2): 111-113. Most, but not all, of these people had heart problems before taking this medicine.

It is not known if sildenafil caused these problems.

Frequently asked questions

↑ Boolell; Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C (1996). «Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction». Health Aff (Millwood) 19 (2): 147-57. «Sales of Impotence Drugs Fall, Defying Expectations». ↑ «Viagra patent expires in June, says Brazilian court».

Side effects and risks

; Freestone, S.; Allen, M.J.; Muirhead, G.J. «Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist». «Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus». «Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial». «Sildenafil for women patients with antidepressant-induced sexual dysfunction». Tell all your healthcare providers that you take sildenafil. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took sildenafil. Sildenafil does not protect you or your partner from getting sexually transmitted diseases, including Human Immunodeficiency Virus (HIV).

Efectos secundarios

«Sildenafil Treatment of Women With Antidepressant-Associated Sexual Dysfunction». «FDA Approves Pfizer's Revatio as Treatment for Pulmonary Arterial Hypertension». «Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension». «Sildenafil for the treatment of altitude-induced hypoxaemia». Expert Opin Pharmacother 6 (5): 835-7.

Can women take Viagra?

«Treatment of high altitude pulmonary edema at 4240 m in Nepal». ↑ «FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems». «Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases». «Sildenafil (Viagra) associated anterior ischemic optic neuropathy». «Sildenafil-associated nonarteritic anterior ischemic optic neuropathy». Sildenafil may cause low blood pressure, which may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy. Tell your doctor if you get more short of breath after you start sildenafil.

• Sildenafil 100mg can be used in combination with other ED treatments if advised.
• Report any persistent side effects to your doctor immediately.
• Avoid taking sildenafil if you have severe cardiovascular disease.
• The medication is not approved for use by women.
• Follow-up with your healthcare provider to evaluate effectiveness.

More shortness of breath than usual may be due to your underlying medical condition. Do not take Viagra while also taking Revatio. These are not all of the possible side effects of sildenafil. You may report side effects to the FDA at 1-800-FDA-1088.

8.2 Lactation

Foster City (California): Biomedical Publications, octava edición, 2008. ↑ Oh S. S., Zou P., Low M. Y., Koh H. L.: «Detection of sildenafil analogues in herbal products for erectile dysfunction», en Journal of Toxicology and Environmental Health (part A).

Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

↑ Venhuis B. J., Blok-Tip L., De Kaste D.: «Designer drugs in herbal aphrodisiacs», en Forensic Science International. «Young men add Viagra to their drug arsenal». «Recreational use and misuse of phosphodiesterase 5 inhibitors». Journal of the American Pharmacists Association 45 (1): 63-75. Have allergies to sildenafil, Viagra, Revatio, Vybrique, or any of the ingredients in the sildenafil formulation you are taking Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines that lower your blood pressure, such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs that also contain nitrates, such as "poppers". To make sure sildenafil is safe for you, tell your healthcare provider about all your medical conditions, including if you have: Or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure Had heart surgery within the last 6 months Low blood pressure, or high blood pressure that is not controlled A physical deformity of the penis (such as Peyronie's disease) Been told you should not have sexual intercourse for health reasons and you are a male Had an erection that lasted for more than 4 hours Problems with your blood cells, such as sickle cell anemia, multiple myeloma, or leukemia Retinitis pigmentosa, a rare genetic (runs in families) eye disease Ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) Kidney problems or are having kidney dialysis Are pregnant or intending to become pregnant (for patients with PAH) Are breastfeeding or intending to breastfeed (for patients with PAH). Sildenafil for ED is not approved for males <18 years old. Sildenafil is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor if they discover they are pregnant. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby.

Implicaciones sociales y utilización no médica

↑ Cunningham; Cunningham AV and Smith KH (2001). «Anterior ischemic optic neuropathy associated with viagra». «A case of nonarteritic ischemic optic neuropathy (NAION) in a male patient taking sildenafil». «Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra». ↑ «FDA Announces Revisions to Labels for Cialis, Levitra and Viagra».

Viagra Tablets

American College of Cardiology/American Heart Association». Journal of the American College of Cardiology 33 (1): 273-82. «Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions». ↑ R. Baselt: Disposition of toxic drugs and chemicals in man (págs. Tell your doctor if you are breastfeeding a baby. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. Take sildenafil oral tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much to take and when to take it. You may take sildenafil between 30 minutes to 4 hours before sexual activity if needed.

12.3 Pharmacokinetics

«Does marijuana use play a role in the recreational use of sildenafil?». Journal of Family Practice 56 (11): 932. «Source: Roger Clemens, host of sildenafil 10mg athletes pop Viagra to help onfield performance». Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation. Sildenafil tablets (25 mg, 50 mg, 100 mg; Viagra, generic) and sildenafil oral film (25 mg, 50 mg, 75 mg, 100 mg; Vybrique) are used for ED. If you take sildenafil after a high-fat meal (such as a cheeseburger and fries), sildenafil may take a little longer to start working. If you accidentally take too much sildenafil, call your doctor or go to the nearest hospital emergency room right away.

• Pfizer Sildenafil 100mg usage should be monitored for adverse effects.
• Some men may need a different dosage for best results.
• The medication can help restore confidence in sexual activity.
• It’s important to combine medication with lifestyle changes.
• Always seek medical advice before starting sildenafil therapy.

Sildenafil can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.