Mechanism of Action for the Dual Therapy Tablet

Do not use Tadalafil Dapoxetine tablets in patients who are using a GC stimulator, such as Riociguat. Tadalafil may potentiate the hypotensive effects of GC stimulators. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Storage Instructions Tadalafil Dapoxetine Tablets have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should not use Tadalafil Dapoxetine tablets if sex is inadvisable due to cardiovascular status.

(FAQ) Frequently Asked Questions

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Dapoxetine, a constituent of this medicine is only indicated in men with Premature Ejaculation who meet all the criteria listed listed earlier. Dapoxetine should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without Premature Ejaculation. Before treatment initiation, a careful medical examination including history of orthostatic events should be performed by the physician. An orthostatic test should be performed before initiating therapy (blood pressure and pulse rate, supine and standing).

What should I tell my healthcare provider before using tadalafil?

In case of a history of documented or suspected orthostatic reaction, treatment with Tadalafil Dapoxetine tablets should be avoided. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Antidepressants, including SSRIs, increased the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. In clinical trials with Dapoxetine, a constituent of Tadalafil Dapoxetine tablets for the treatment of premature ejaculation, there was no clear indication of treatment-emergent suicidality in evaluation of possibly suicide-related adverse events. Patients should avoid operating hazardous machinery, should syncope or its prodromal symptoms such as dizziness or lightheadedness occur.

Study Locations

The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with recreational drugs. Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with alcohol. Combining alcohol with dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental sildenafil dapoxetine tablets injury; therefore, patients should be advised to avoid alcohol while taking Tadalafil Dapoxetine tablets . Tadalafil Dapoxetine tablets should be prescribed with caution in patients taking medicinal products with vasodilatation properties (such as alpha adrenergic receptor antagonists and nitrates) due to possible reduced orthostatic tolerance. Use of Tadalafil Dapoxetine tablets with alpha blockers, antihypertensives or substantial amounts of alcohol (5 units or greater) may lead to hypotension.

This medicine is not recommended in combination with alpha blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. Caution is advised when Tadalafil Dapoxetine tablets are used as a treatment for ED in men taking alpha blockers.

Warnings & Precautions

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose Single doses up to 500 mg of Tadalafil have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose No case of Dapoxetine overdose has been reported. There were no unexpected adverse events in a clinical pharmacology study of Dapoxetine with daily doses up to 240 mg (two 120 mg doses given 3 hours apart).

Long-Term Effects

In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. Due to high protein binding and large volume of distribution of Dapoxetine Hydrochloride, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit. No specific antidotes for Dapoxetine are known. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets During Pregnancy This is a combination medication containing Tadalafil and Dapoxetine Hydrochloride. Tadalafil has been classified by the US FDA as Pregnancy Category B. Tadalafil Dapoxetine tablets are not suitable and should not be used if taking potent inhibitors of CYP3A4. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should seek emergency treatment if an erection lasts for more than 4 hours. Use Tadalafil Dapoxetine tablets with caution in patients predisposed to priapism. Patients should stop Tadalafil Dapoxetine tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of Non Arteritic Ischemic Optic Neuropathy (NAION). Discuss increased risk of NAION in patients with history of NAION. Patients should stop Tadalafil Dapoxetine tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Dapoxetine, a constituent of this medicine is only indicated in men with Premature Ejaculation who meet all the criteria listed listed earlier.

Limitations of the study

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings This medicine is not suitable in patients taking moderate CYP3A4 inhibitors and in patients taking potent CYP2D6 inhibitors since the Dapoxetine dose is restricted to 30 mg. Tadalafil Dapoxetine tablets should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders. Due to the potential of SSRIs to lower the seizure threshold, Tadalafil Dapoxetine tablets should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy. Patients with controlled epilepsy should be carefully monitored. Tadalafil Dapoxetine tablets should not be used in individuals below 18 years of age.

Rare but Serious Side Effects

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Tadalafil Dapoxetine tablets are not indicated for psychiatric disorders and should not be used in men with these disorders, such as schizophrenia, or in those suffering with co-morbid depression, as worsening of symptoms associated with depression cannot be excluded. There have been reports of bleeding abnormalities with SSRIs. Caution is advised in patients taking this medicine, particularly in concomitant use with medicinal products known to affect platelet function or anticoagulants, as well as in patients with a history of bleeding or coagulation disorders. Tadalafil Dapoxetine tablets are not recommended for use in patients with severe renal impairment and caution is advised in patients with mild or moderate renal impairment. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this Tadalafil Dapoxetine tablets.

What are the most common side effects of tadalafil?

The use of Dapoxetine, a constituent of Tadalafil Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain. Dapoxetine should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Withdrawal Effects Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia and hypomania. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Possible Side Effects Most common side effects Tadalafil Dapoxetine Combination tablets are increased thirst and a light-headedness following sudden movements - this is natural, as blood moves into the genital areas. The common side effects include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, nausea, dizziness, diarrhoea, insomnia,fatigue and pain in limb. Dapoxetine should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without Premature Ejaculation.

How long does dapoxetine make me last?

Do not use Tadalafil Dapoxetine tablets in patients who are using a GC stimulator, such as Riociguat. Tadalafil may potentiate the hypotensive effects of GC stimulators. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Storage Instructions Tadalafil Dapoxetine Tablets have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets.

Who should not use tadalafil?

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should not use Tadalafil Dapoxetine tablets if sex is inadvisable due to cardiovascular status. Use of Tadalafil Dapoxetine tablets with alpha blockers, antihypertensives or substantial amounts of alcohol (5 units or greater) may lead to hypotension. This medicine is not recommended in combination with alpha blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. Caution is advised when Tadalafil Dapoxetine tablets are used as a treatment for ED in men taking alpha blockers. Tadalafil Dapoxetine tablets are not suitable and should not be used if taking potent inhibitors of CYP3A4.

Dosage Adjustments

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should seek emergency treatment if an erection lasts for more than 4 hours. Use Tadalafil Dapoxetine tablets with caution in patients predisposed to priapism. Patients should stop Tadalafil Dapoxetine tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of Non Arteritic Ischemic Optic Neuropathy (NAION). Discuss increased risk of NAION in patients with history of NAION. Patients should stop Tadalafil Dapoxetine tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing. Before treatment initiation, a careful medical examination including history of orthostatic events should be performed by the physician. An orthostatic test should be performed before initiating therapy (blood pressure and pulse rate, supine and standing). In case of a history of documented or suspected orthostatic reaction, treatment with Tadalafil Dapoxetine tablets should be avoided. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Antidepressants, including SSRIs, increased the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. In clinical trials with Dapoxetine, a constituent of Tadalafil Dapoxetine tablets for the treatment of premature ejaculation, there was no clear indication of treatment-emergent suicidality in evaluation of possibly suicide-related adverse events. Patients should avoid operating hazardous machinery, should syncope or its prodromal symptoms such as dizziness or lightheadedness occur. The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with recreational drugs.

Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with alcohol. Combining alcohol with dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental sildenafil dapoxetine tablets injury; therefore, patients should be advised to avoid alcohol while taking Tadalafil Dapoxetine tablets .

• Tadalafil and dapoxetine are usually taken 30-60 minutes before sex.
• The combination can be used on demand or as prescribed by a doctor.
• Patients should report any prolonged erections or severe side effects immediately.
• The medication should not be used with nitrates or certain blood pressure medicines.
• Pregnant or breastfeeding women should avoid using these tablets.
• Proper storage away from moisture and heat preserves drug efficacy.

Tadalafil Dapoxetine tablets should be prescribed with caution in patients taking medicinal products with vasodilatation properties (such as alpha adrenergic receptor antagonists and nitrates) due to possible reduced orthostatic tolerance. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings This medicine is not suitable in patients taking moderate CYP3A4 inhibitors and in patients taking potent CYP2D6 inhibitors since the Dapoxetine dose is restricted to 30 mg. Tadalafil Dapoxetine tablets should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders. Due to the potential of SSRIs to lower the seizure threshold, Tadalafil Dapoxetine tablets should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy. Patients with controlled epilepsy should be carefully monitored. Tadalafil Dapoxetine tablets should not be used in individuals below 18 years of age. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Tadalafil Dapoxetine tablets are not indicated for psychiatric disorders and should not be used in men with these disorders, such as schizophrenia, or in those suffering with co-morbid depression, as worsening of symptoms associated with depression cannot be excluded.

There have been reports of bleeding abnormalities with SSRIs. Caution is advised in patients taking this medicine, particularly in concomitant use with medicinal products known to affect platelet function or anticoagulants, as well as in patients with a history of bleeding or coagulation disorders. Tadalafil Dapoxetine tablets are not recommended for use in patients with severe renal impairment and caution is advised in patients with mild or moderate renal impairment. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this Tadalafil Dapoxetine tablets. The use of Dapoxetine, a constituent of Tadalafil Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain. Dapoxetine should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Withdrawal Effects Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia and hypomania. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Possible Side Effects Most common side effects Tadalafil Dapoxetine Combination tablets are increased thirst and a light-headedness following sudden movements - this is natural, as blood moves into the genital areas. The common side effects include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, nausea, dizziness, diarrhoea, insomnia,fatigue and pain in limb.

• Tadalafil with dapoxetine is available under various brand names globally.
• Side effects may include headache, dizziness, nausea, or flushing.
• It’s important to follow prescribed dosages to minimize adverse effects.
• These tablets are not suitable for individuals with certain heart conditions.
• Do not mix with alcohol, as it can increase side effects and reduce effectiveness.
• Always consult a healthcare professional before starting this medication.

© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose Single doses up to 500 mg of Tadalafil have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients.

• Tadalafil with dapoxetine is available in tablet form and is taken orally.
• A typical dose is one tablet 30-60 minutes before sexual activity.
• The medication is designed for use as needed, not daily use.
• Patients should avoid heavy or fatty meals close to taking the medication.
• Dapoxetine works best when taken with a full glass of water.
• Tadalafil helps sustain an erection for longer periods.

Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose No case of Dapoxetine overdose has been reported. There were no unexpected adverse events in a clinical pharmacology study of Dapoxetine with daily doses up to 240 mg (two 120 mg doses given 3 hours apart). In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. Due to high protein binding and large volume of distribution of Dapoxetine Hydrochloride, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit. No specific antidotes for Dapoxetine are known. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets During Pregnancy This is a combination medication containing Tadalafil and Dapoxetine Hydrochloride. Tadalafil has been classified by the US FDA as Pregnancy Category B.